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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IL6ST All Species: 22.73
Human Site: Y683 Identified Species: 55.56
UniProt: P40189 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P40189 NP_002175.2 918 103537 Y683 F N S K D Q M Y S D G N F T D
Chimpanzee Pan troglodytes XP_001144341 918 103578 Y683 F N S K D Q M Y S D G N F T D
Rhesus Macaque Macaca mulatta XP_001100601 918 103709 Y683 F S S K D Q M Y S D G N F T D
Dog Lupus familis XP_535239 857 96713 E636 D V S V V E I E A A N D K K P
Cat Felis silvestris
Mouse Mus musculus Q00560 917 102434 Y681 F N S K D Q M Y S D G N F T D
Rat Rattus norvegicus P40190 918 102432 Y682 F N S K D Q M Y S D A N F T D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505316 793 88837 T572 I Y P E G C L T D V S V V E L
Chicken Gallus gallus NP_990202 918 102477 Y687 F S S K D Q M Y P E G S F T D
Frog Xenopus laevis NP_001124412 881 98985 Q657 P S K S N I A Q W S P Q T P N
Zebra Danio Brachydanio rerio NP_001106976 866 98131 I645 A D G E V E M I V V L V C L G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.5 85.9 N.A. 77 78.6 N.A. 56.6 59.4 44.9 35.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.6 98.6 88.8 N.A. 86.7 87.4 N.A. 67 72.2 58.2 51.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 6.6 N.A. 100 93.3 N.A. 0 73.3 0 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 33.3 N.A. 100 93.3 N.A. 13.3 93.3 20 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 0 10 0 10 10 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 10 0 0 % C
% Asp: 10 10 0 0 60 0 0 0 10 50 0 10 0 0 60 % D
% Glu: 0 0 0 20 0 20 0 10 0 10 0 0 0 10 0 % E
% Phe: 60 0 0 0 0 0 0 0 0 0 0 0 60 0 0 % F
% Gly: 0 0 10 0 10 0 0 0 0 0 50 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 10 10 10 0 0 0 0 0 0 0 % I
% Lys: 0 0 10 60 0 0 0 0 0 0 0 0 10 10 0 % K
% Leu: 0 0 0 0 0 0 10 0 0 0 10 0 0 10 10 % L
% Met: 0 0 0 0 0 0 70 0 0 0 0 0 0 0 0 % M
% Asn: 0 40 0 0 10 0 0 0 0 0 10 50 0 0 10 % N
% Pro: 10 0 10 0 0 0 0 0 10 0 10 0 0 10 10 % P
% Gln: 0 0 0 0 0 60 0 10 0 0 0 10 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 30 70 10 0 0 0 0 50 10 10 10 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 10 0 0 0 0 10 60 0 % T
% Val: 0 10 0 10 20 0 0 0 10 20 0 20 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 0 0 60 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _